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The only problem i can see is medical, as in you need someone to provide aide when you get sick, otherwise a hermit mode could be a challenging experience!
I'm currently playing on a ice sheet biome with just one guy, lots of micromanaging! But it is pretty satisfying.
With the harder crafting mods that are out there (personally im using Ninefingers ultimate modpack) you really need to pay attention to what your colonist is doing!
I assume a mod or modpack would be needed to work around some of the limitations of being alone.

Just wondering if someone could throw together a hugely combat focused storyteller as right now im not being attacked enough! i dont mean local animals going nuts either, randy takes care of that

thanks