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In retrorespect i don't have that many runs to draw experience from but here goes:
I now usually play on randy random - rough. Moving away from the general temperate climate to more colder regions, but nothing to extreme.

Day1
A roofed stockpile and a roofed place to sleep. Get the starting goods into the stockpile. Start growing food (especially with the longer grow-time in A17) and then start securing perimeter (walling in).
Day2
After finishing walling in the next project is the freezer. I might setup a butchers table and campfire for temporary food-measures depending on how much food i have. Also add a table and chair to the main room.
Day3
Proper setup of a kitchen. Start working on private bedrooms and a general dining room. After that it would be the workshop and fortifying defenses.

That is all for major building projects. Gaining resources and food (hunting) will go alongside depending on available labor and needs.

I haven't played that much with A17 yet but i noticed one minor annoyance in the last playthrough.
With wild healroot and the ability to self-tend i tried a solo-run (custom scenario, start with nothing). Was quite challenging and i lasted 11 days. What killed me in the end was malaria and here is the thing: Despite being herb medicine available, self-tend activated and the diesase requireing tending my pawn decided to stay in bed for nearly a day - in hindsight i should have dropped the priority of patient - and i was unable to force him to tend himself.
With other pawns it is possible to override their current action and force a pawn to tend another one, apparently that is not possible if doctor and patient are the same person.