From what I hear, this means that some unity graphics settings are screwy (usually something to do with active window). Have you checked your configs?
Not sure where it is in Windows 10, but in Windows 7 it's in %appdata%\..\LocalLow\Ludeon Studios\RimWorld by Ludeon Studios\config
Have a look at the prefs.xml file, and try changing <fullscreen>True</fullscreen> to <fullscreen>False</fullscreen> and see if that helps.
Edit: Someone else who had the same\similar problems: https://ludeon.com/forums/index.php?topic=26517.msg268946#msg268946
Not sure where it is in Windows 10, but in Windows 7 it's in %appdata%\..\LocalLow\Ludeon Studios\RimWorld by Ludeon Studios\config
Have a look at the prefs.xml file, and try changing <fullscreen>True</fullscreen> to <fullscreen>False</fullscreen> and see if that helps.
Edit: Someone else who had the same\similar problems: https://ludeon.com/forums/index.php?topic=26517.msg268946#msg268946