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Some workbenches actually reduce cleanliness, by the way. So don't build them in the same room as your stove(s).

Wish I'd known that long ago - lol.  My "main production room" has nearly all of my workbenches, including 4 stoves.

That said, very few of my pawns refuse to clean and most have cleaning as a high priority, so it hasn't been a problem.

A messy, dirty lab isn't  usually indicative of quality research, let's say.

I use a "distributed turret" system (4 turrets separated by a "plus sign" of granite to prevent losing all to one failing, all over the map with overlapping coverage) so nearly all hostile events are..."diluted in risk", let's say; literally no part of the open map area escapes coverage ^^' .  And you gotta have some challenge, right?
The only event I can't do all that much about ahead of time is sickness, and I just learn to deal.

I dunno; deep drilling yields a LOT of w/e resource, usually.  That and trading is usually where I get the vast majority of my steel/plasteel, anyhow, so *shrug* .

Remember, don't start stockpiling too much valuable stuff too early!  You'll invite strong raids.

I raise dogs of w/e sort and bears.  Both can haul and are useful in defense, and also give the "master of a bonded animal" mood bonus.  My food "machine" is efficient enough to pump out plenty of surplus meals (I keep a base of 300 simple meals on hand at all times, no matter what, then hoard from there) so it's not (yet) an issue re: resource drain.

And what's cooler than a large, well-armed art colony, with guard bears?

I'd use ALL bears but unlike bears, dogs will work with any colonist as the master, skilled or not.