I feel like that just doesn't fit with Rimworld. It's always been about struggling to survive, and using the same engine but making it about building a business simulator or something would mean a lot of features(such as the intricate psychology and damage) would be unused or feel weird. The way you've described these possible sequels, it feels like Rimworld but without really big negative events, and with profit generating tacked on.
Honestly it sounds like the current endgame, with no real challenge, but for the whole game.
Honestly it sounds like the current endgame, with no real challenge, but for the whole game.