Ship cryptosleep is kind of unnessacary

[Canute]

Yep shurp is right.
On a nuclear fission/fussion reaction only less then 1% of the materia get converted into energy.
Compared to the MAM reaction which all materia get converted into energy.

But at this kind of spaceflight you allways need to watch on fuel, and it will be very difficult to generate new antimatter (Zyclotron + high energy cost).
Compared to gather new fission material from asteroids or extraction fussion mater from water or mining He3.

[Shurp]

That depends on what sort of technology you're using to create antimatter.  If you have a quantum phase inverter that simply rotates the charge oscillation by 180' out of phase, woo hoo, free antimatter.

Oh, wait, you wanted *science*, not science fiction?

Ummm.... in that case you're more likely to use a charged black hole as your power source than antimatter.  That's at least possible with known physics.  But the Hawking radiation for small black holes is huge.  The challenge will be keeping it fed enough to keep it large and stable!

Hmmm, actually, that might not work well.  A 72,000 ton black hole will last a year, yes, but it's putting out 16 megatons (TNT) of energy every second.  Not sure where you're going to dump all that power!!!  And a million ton black hole is still putting out 100 kT per second.  It seems like any spaceship powered by a black hole is basically using all its energy to push the black hole around.

http://xaonon.dyndns.org/hawking/

Ahhh, the billion ton black holes are "reasonable" -- only 356 megawatts of power coming out.  But what sort of magnetic containment field can support a near point mass weighing a billion tons?

[Canute]

Yeah a quantum phase inverter or a quantum materia recombinator would indeed the better solution to create antimatter, since you don't create new materia and don't need the energy for these.
Just the energy for the transformation process.
But don't you think if a civilisation got this kind of technology they can't use it for a quantum reactor which turn any materia into energy without the detour over antimatter ? :-)

And about the black hole, like you mention you need to move the mass of the black hole together with the ship. So that black hole should be rather small :-)