There's not a lot of things I don't do because I like, morally object to, like my colonists rarely do drugs only because I can't be arsed to make them myself and I don't want to deal with addiction/withdrawal, not because I'm a prohibitionist.
I think the only thing is, I won't kill/execute/sell into slavery/position them near raiders any of my colonists because they're useless. I've executed them if they've committed severe enough crimes during a rage. And I euthanised one who was braindead (Which was one of those most memorable things I've done in the game), and I won't rescue sailors or sheriffs from bandit camps or raiders. But once they're in my colony, I try to protect them best I can and find the best use out of them I can.
I think the only thing is, I won't kill/execute/sell into slavery/position them near raiders any of my colonists because they're useless. I've executed them if they've committed severe enough crimes during a rage. And I euthanised one who was braindead (Which was one of those most memorable things I've done in the game), and I won't rescue sailors or sheriffs from bandit camps or raiders. But once they're in my colony, I try to protect them best I can and find the best use out of them I can.