Oh dear, I have a feeling my mod might be responsible for this. Is there anything strange in your output_log.txt after this happens? Perhaps it would help if you posted your output_log.txt here.
Edit: I have a feeling this has to do with the "Stay inside during threats" option on the second page of the Vanilla+ menu. Maybe your colonist will become unstuck when you toggle it?
The way that option works is it prevents colonists from taking new jobs outside of your home region, but maybe it has some unexpected side effects for colonists who are already outside, is the colonist blocked in any way from going back to the home region by any chance? Perhaps by one of those special doors?
I guess an easy way to fix it is to change it so colonists that are already outside are unaffected by that option.
Edit2: I uploaded a new version of Vanilla+, hopefully it fixes everything. I'd still like to see your output_log.txt though if that's alright, because the menus going all unresponsive does worry me a little.